Endocrine Abstracts

Cycline D1 gene that plays a crucial role in a cell cycle, have been shown to be expressed more in nonfunctioning pituitary adenomas and functioning invasive pituitary adenomas compared to normal hypophisis tissue and noninvasive pituitary adenomas. A/G polymorphism in CyD1 gene exon 4/intron 4 regions have been demonstrated to affect clinical outcomes and survey in some tumors. Objective of this study was to investigate the effect of polymorphism of cycline D1 gene on the tum...

Majority of prolactinomas consists of the small microadenomas that can be treated with dopamine agonists, but they can present different biological behavior features and not infrequently seen as macroadenomas or in giant adenoma size. There are different results on finding of studies which investigate the relationship between high levels of cell proliferation indicators with tumor behavior in pituitary adenomas. In this study, Ki 67 index to investigate the relationship betwee...

Introduction: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance and related disorders. Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflammation. But there are controversial data whether increased the uric acid level in PCOS patients. This study was aimed to examine the relationship between uric acid, lipoprotein l...

In prolactin secreting pituitary adenomas, surgery markedly reduced with the efficacy of dopamine agonists in controlling prolactin hypersecretion and reducing tumor mass. Some surgeons, instead of necessity of almost life-long medical therapy, prefer and recommend surgery as a first line treatment with potentially high success rates especially in microprolactinomas. We evaluated our patients with prolactinoma operated mostly without any evidence of resistance or intolerance t...

Introduction: Hyalinizing trabecular adenomas (HTA) of the thyroid is an unusual disorder. HTA can be present as a thyroid nodule or incidental finding in a thyroidectomy specimen. Most behave as benign neoplasms, but their cytological features can be similar to those of papillary thyroid carcinoma.Case report: A 68 year old woman admitted to our institution with a solitary thyroid nodüle. Her serum free thyroxine (fT4), free triiodothyro...

Background: Sitagliptin, unlike the some major antihyperglycaemic drugs, is not associated with weight gain and has neutral effects on body weight. It is unclear whether sitagliptin treatment alters serum ghrelin levels in people with type 2 diabetes. The aim of the present study was to assess the effect of sitagliptin on serum ghrelin levels in patients with type 2 diabetes mellitus.Methods: Forty-four type 2 diabetic subjects were randomly assigned to ...

Thyroidectomy is an alternative treatment in the therapy of hyperthyroidism in patients who are non-compliant, drug-resistant or have various side effects to the antithyroid drugs. Preoperative preparation of hyperthyroid patients is extremely important to avoid per operative complications due to severe thyrotoxicosis. We investigated the effects of lugol solution usage with or without thionamides in the rapid preparation of thyroid surgery retrospectively. Twenty-two patients...

Background: Atypical parathyroid adenoma (APA) is a rare disease that can be challenging to distinguish from benign parathyroid adenoma. APA shows some laboratory and histopathological features with parathyroid cancer. This study attempts to compare clinical, laboratory, radiologic and histopathological characteristics in APA and parathyroid adenoma (PA).Methods: This was a retrospective study was based on the database of eighty-two subjects who underwen...

Introduction: Brown tumor refers to the skeletal change that develops as one of the complications of hyperparathyroidism, in which cystic and fibrous changes occur in the bone. It occurs in approximately 10−20% of patients with primary hyperparathyroidism. Parathyroid cancer is a rare cause of primary hyperparathyroidism and accounts for approximately 1% of cases. In some cases, hyperparathyroidism may be asymptomatic until it becomes a pathological fracture and may be t...

Introduction: Hemichorea-hemiballismus, secondary to hyperglycemia, is a rare but easily treatable condition that is usually associated with poorly controlled type II diabetes mellitus. Diagnosis is based on clinical assessment and imaging. Etiology includes primarily cerebrovascular diseases, metabolic, degenerative, infectious diseases, space-occupying lesions, basal ganglia damage due to drugs and toxic substances.Case: Here we report a rare case of a...